Medicina news

JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies

The IFN-mediated autoinflammatory diseases CANDLE (chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures) and SAVI (stimulator of IFN genes–associated [STING-associated] vasculopathy with onset in infancy) are Mendelian innate immune–dysregulatory disorders that present early in life with fevers, sterile organ inflammation, and a high type I IFN response gene signature (IRS) in peripheral blood cells (1, 2) and are part of the spectrum of conditions termed interferonopathies (3).

Leggi tutto l'articolo sul sito www.jci.org

Recommendations for managing PD-1 blockade in the context of allogeneic HCT in Hodgkin lymphoma: taming a necessary evil

PD-1 blockade is associated with high response rates and durable benefit in patients with relapsed/refractory (R/R) classical Hodgkin lymphoma (cHL) who have relapsed after or are ineligible for autologous hematopoietic cell transplantation (auto-HCT).1-5

Leggi tutto l'articolo sul sito www.bloodjournal.org

TNF overproduction impairs epithelial staphylococcal response in hyper IgE syndrome

(Ian A. Myles, … , Steven M. Holland, Sandip K. Datt)
J Clin Invest

Autosomal dominant hyper IgE syndrome (AD-HIES), or Job’s syndrome, is a primary immune deficiency caused by dominant-negative mutations in STAT3. Recurrent Staphylococcus aureus skin abscesses are a defining feature of this syndrome.

Leggi tutto l'articolo sul sito https://doi.org/10.1172/JCI121486

Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche

(Shokichi Tsukamoto, Marianne B. Løvendorf[…] & Irene M. Ghobrial)

Myeloma bone disease is a devastating complication of multiple myeloma (MM) and is caused by dysregulation of bone remodeling processes in the bone marrow microenvironment. Previous studies showed that microRNA-138 (miR-138) is a negative regulator of osteogenic differentiation of mesenchymal stromal cells (MSCs) and that inhibiting its function enhances bone formation in vitro.

Leggi tutto l'articolo sul sito https://www.nature.com/articles/s41375-018-0161-6

A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small-cell lung cancer treated with PD-1 blockade

(Daniela S. Thommen, Viktor H. Koelzer[…] & Alfred Zippelius)
Nature Medicine

Evidence from mouse chronic viral infection models suggests that CD8+ T cell subsets characterized by distinct expression levels of the receptor PD-1 diverge in their state of exhaustion and potential for reinvigoration by PD-1 blockade. However, it remains unknown whether T cells in human cancer adopt a similar spectrum of exhausted states based on PD-1 expression levels.

Leggi tutto l'articolo sul sito https://www.nature.com/articles/s41591-018-0057-z

Angelo Vacca, MD, PhD

Professor of Medicine
Department of Biomedical Sciences and Human Oncology
Chief Clinica Medica "G. Baccelli"
University of Bari Medical School
I-70124 BARI (Italy)

Phone +39-080-5478057
Fax +39-080-5592189
e-mail angelo.vacca@uniba.it