PD-1 blockade is associated with high response rates and durable benefit in patients with relapsed/refractory (R/R) classical Hodgkin lymphoma (cHL) who have relapsed after or are ineligible for autologous hematopoietic cell transplantation (auto-HCT).^1⇓⇓⇓-5

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(Ian A. Myles, … , Steven M. Holland, Sandip K. Datt)
J Clin Invest

Autosomal dominant hyper IgE syndrome (AD-HIES), or Job’s syndrome, is a primary immune deficiency caused by dominant-negative mutations in STAT3. Recurrent Staphylococcus aureus skin abscesses are a defining feature of this syndrome.

Leggi tutto l'articolo sul sito https://doi.org/10.1172/JCI121486

(Shokichi Tsukamoto, Marianne B. Løvendorf[…] & Irene M. Ghobrial)
Leukemia

Myeloma bone disease is a devastating complication of multiple myeloma (MM) and is caused by dysregulation of bone remodeling processes in the bone marrow microenvironment. Previous studies showed that microRNA-138 (miR-138) is a negative regulator of osteogenic differentiation of mesenchymal stromal cells (MSCs) and that inhibiting its function enhances bone formation in vitro.

Leggi tutto l'articolo sul sito https://www.nature.com/articles/s41375-018-0161-6

(Daniela S. Thommen, Viktor H. Koelzer[…] & Alfred Zippelius)
Nature Medicine

Evidence from mouse chronic viral infection models suggests that CD8+ T cell subsets characterized by distinct expression levels of the receptor PD-1 diverge in their state of exhaustion and potential for reinvigoration by PD-1 blockade. However, it remains unknown whether T cells in human cancer adopt a similar spectrum of exhausted states based on PD-1 expression levels.

Leggi tutto l'articolo sul sito https://www.nature.com/articles/s41591-018-0057-z